Can You Take Alpha-GPC and CDP-Choline (Citicoline) Together?

Dose or timing may matter

The short answer

Both CDP-Choline (Citicoline) and Alpha-GPC are high-bioavailability choline donors. Combining them provides excessive choline substrate, which may lead to cholinergic overload symptoms including headaches, nausea, and digestive upset.

How to arrange timing

Choose one choline source rather than stacking both. If combining, use half the typical dose of each and monitor for headaches.

Reference

Reference noted for this combination: Secades JJ, Lorenzo JL. Citicoline: pharmacological and clinical review, 2006 update. Methods Find Exp Clin Pharmacol. 2006;28(Suppl B):1-56.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.