Can You Take Alpha-Galactosidase and Probiotics Together?

May affect absorption

The short answer

Alpha-Galactosidase breaks down oligosaccharides that serve as food sources (prebiotics) for probiotic bacteria. Simultaneous intake may reduce the prebiotic substrate available for probiotic colonization.

How to arrange timing

Take probiotics at least 1 hour apart from Alpha-Galactosidase to preserve the prebiotic environment in the gut.

Reference

Reference noted for this combination: Montalto M, et al. Effect of exogenous alpha-galactosidase on intestinal gas production. Eur J Clin Nutr. 2008;62(12):1470-1474.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.