Can You Take Alpha-Galactosidase and Inulin Together?

Dose or timing may matter

The short answer

Alpha-Galactosidase breaks down oligosaccharides including some prebiotic fibers. Taking it with Inulin may partially reduce the prebiotic effect by degrading oligosaccharide chains before they reach the colon.

How to arrange timing

Take Inulin separately from Alpha-Galactosidase. Use the enzyme with meals and the prebiotic between meals.

Reference

Reference noted for this combination: Di Stefano M, et al. The effect of oral alpha-galactosidase on intestinal gas production and gas-related symptoms. Dig Dis Sci. 2007;52(1):78-83.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.