Can You Take Acid Protease and Collagen Together?

Dose or timing may matter

The short answer

Acid Protease can hydrolyze collagen peptide bonds in the acidic stomach environment, potentially reducing the effective dose of collagen supplements taken simultaneously.

How to arrange timing

Separate Acid Protease and Collagen by at least 1 hour. Take collagen on an empty stomach and enzymes with meals.

Reference

Reference noted for this combination: Rao MB, et al. Molecular and biotechnological aspects of microbial proteases. Microbiol Mol Biol Rev. 1998;62(3):597-635.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.