Can You Take Valerian Root and 5-HTP Together?

Use extra care with this pair

The short answer

Valerian enhances GABA activity while 5-HTP increases serotonin. Combined use may lead to excessive sedation or, rarely, serotonin-related side effects.

How to arrange timing

Avoid combining, or use under healthcare supervision.

Reference

Reference noted for this combination: NIH NCCIH

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.