Does Grapefruit Affect Quercetin?

May affect absorption or how you feel

The short answer

Quercetin inhibits CYP3A4 and P-glycoprotein similar to grapefruit. Combined intake may cause additive enzyme/transporter inhibition.

How to arrange timing

Separate quercetin from grapefruit by 2 hours if taking other CYP3A4-metabolized supplements.

Reference

Reference noted for this food and supplement combination: Choi et al., Arch Pharm Res 2011; Examine.com

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.