Does Grapefruit Affect Naringenin?

May affect absorption or how you feel

The short answer

Naringenin is the primary CYP3A4-inhibiting compound in grapefruit. Supplemental naringenin plus grapefruit causes additive CYP3A4 inhibition.

How to arrange timing

Do not take naringenin supplements alongside grapefruit — the interaction is additive.

Reference

Reference noted for this food and supplement combination: Bailey et al., Am J Clin Nutr 2006

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.