Does Grapefruit Affect Hesperidin?

May affect absorption or how you feel

The short answer

Hesperidin is metabolized by CYP enzymes and also modulates P-glycoprotein. Grapefruit may alter hesperidin metabolism and amplify its effects.

How to arrange timing

Separate hesperidin supplements from grapefruit by 2 hours.

Reference

Reference noted for this food and supplement combination: Examine.com; Nielsen et al., Eur J Clin Nutr 2006

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.