Does Grapefruit Affect Fish Oil (Omega-3)?

May affect absorption or how you feel

The short answer

High-dose omega-3 fatty acids are partially CYP-metabolized. Grapefruit's P-glycoprotein inhibition may modestly alter EPA/DHA absorption.

How to arrange timing

Separate fish oil from grapefruit by 2 hours at high doses.

Reference

Reference noted for this food and supplement combination: Examine.com

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.