Does Grapefruit Affect Ashwagandha?

Amount or timing may matter

The short answer

Grapefruit inhibits CYP3A4 enzyme, potentially increasing ashwagandha blood levels unpredictably.

How to arrange timing

Avoid grapefruit within 4 hours of ashwagandha.

Reference

Reference noted for this food and supplement combination: FDA

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.