Does Caffeine Affect Vitamin B3?

May affect absorption or how you feel

The short answer

Caffeine's diuretic effect increases urinary excretion of water-soluble niacin (B3), reducing its effective retention.

How to arrange timing

Take niacin at least 1 hour apart from caffeinated beverages.

Reference

Reference noted for this food and supplement combination: NIH ODS 2024

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.