Does Caffeine Affect Magnolia Bark?

Amount or timing may matter

The short answer

Honokiol and magnolol in magnolia bark are GABA-A receptor positive allosteric modulators. Caffeine counteracts their sedative and anxiolytic action.

How to arrange timing

Avoid caffeine at least 6 hours before taking magnolia bark for sleep or anxiety.

Reference

Reference noted for this food and supplement combination: Examine.com 2024; Alexeev et al. 2012

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.