Does Caffeine Affect Folate?

May affect absorption or how you feel

The short answer

Caffeine's diuretic effect increases renal clearance of folate. Coffee polyphenols may also interfere with folate absorption.

How to arrange timing

Take folate at least 1 hour apart from coffee or caffeinated drinks.

Reference

Reference noted for this food and supplement combination: NIH ODS 2024; Examine.com

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.