Does Caffeine Affect Bacopa Monnieri?

Amount or timing may matter

The short answer

Bacopa has calming, anxiolytic properties via serotonin modulation. Caffeine's stimulatory and cortisol-raising effects can counteract bacopa's cognitive-calming benefits.

How to arrange timing

Separate bacopa from caffeine by at least 2 hours for best anxiolytic benefit.

Reference

Reference noted for this food and supplement combination: Examine.com 2024; Calabrese et al. 2008

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.