Does Caffeine Affect Apigenin?

Amount or timing may matter

The short answer

Apigenin binds GABA-A receptors and promotes relaxation and sleep. Caffeine's CNS stimulation directly counteracts these sedative effects.

How to arrange timing

Separate apigenin from caffeine by at least 4 hours when using for sleep support.

Reference

Reference noted for this food and supplement combination: Examine.com 2024; Viola et al. 1995

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.