Does Caffeine Affect 5-HTP?

Amount or timing may matter

The short answer

5-HTP raises serotonin to promote calm and sleep. Caffeine increases cortisol and norepinephrine, partially counteracting serotonergic calming effects.

How to arrange timing

Separate 5-HTP from caffeine by at least 4 hours, especially for sleep support.

Reference

Reference noted for this food and supplement combination: Examine.com 2024

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.