Does Alcohol Affect Vitamin B3?

Use extra care with this combination

The short answer

Both alcohol and high-dose niacin are hepatotoxic. Combining them significantly increases risk of liver damage and flushing.

How to arrange timing

Avoid alcohol entirely when taking high-dose niacin (B3).

Reference

Reference noted for this food and supplement combination: FDA; NIH ODS 2024

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.