Can You Take Synephrine and Yohimbine Together?

Dose or timing may matter

The short answer

Synephrine (bitter orange) and yohimbine are both sympathomimetic agents that raise blood pressure. Synephrine activates alpha-1 receptors while yohimbine blocks alpha-2 autoreceptors. Combined use may cause significant BP elevation.

How to arrange timing

Research suggests caution when combining sympathomimetic agents. Monitor blood pressure and heart rate closely.

Reference

Reference noted for this combination: Stohs SJ et al. A review of the human clinical studies involving Citrus aurantium (bitter orange) extract. Phytother Res. 2012;26(3):317-324

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.