Can You Take Synephrine and Valerian Root Together?

Dose or timing may matter

The short answer

Synephrine's adrenergic stimulation may counteract valerian's GABAergic sedative effects.

How to arrange timing

Separate by several hours for best results.

Reference

Reference noted for this combination: Stohs et al., 2012, Phytother Res

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.