Can You Take St. John's Wort and SAMe Together?

Use extra care with this pair

The short answer

Both increase serotonin levels. Combining raises risk of serotonin syndrome.

How to arrange timing

Do not combine. Serious risk of serotonin syndrome.

Reference

Reference noted for this combination: NCCIH 2024

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.