Can You Take Saffron Extract and Valerian Root Together?

Use extra care with this pair

The short answer

Valerian Root has partial agonist activity at serotonin 5-HT5a receptors, and Saffron Extract also modulates serotonergic pathways. Combining them may produce additive serotonergic effects.

How to arrange timing

Monitor for excessive sedation or serotonin-related symptoms when combining Valerian Root with Saffron Extract.

Reference

Reference noted for this combination: Dietz BM, et al. Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. Mol Brain Res. 2005;138(2):191-197.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.