Can You Take Rue and Turmeric / Curcumin Together?

Use extra care with this pair

The short answer

Both Rue and Turmeric / Curcumin have MAO-inhibiting properties. Combining multiple MAO inhibitors may impair serotonin metabolism, leading to elevated serotonin levels and increased risk of serotonin syndrome.

How to arrange timing

Avoid stacking Rue with Turmeric / Curcumin. If using both for different health goals, consult a healthcare provider about safe timing and dosing.

Reference

Reference noted for this combination: Gillman PK. Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. Br J Anaesth. 2005;95(4):434-441.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.