Can You Take Rhodiola Crenulata and Saffron Extract Together?

Use extra care with this pair

The short answer

Both Rhodiola Crenulata and Saffron Extract have MAO-inhibiting properties. Combining multiple MAO inhibitors may impair serotonin metabolism, leading to elevated serotonin levels and increased risk of serotonin syndrome.

How to arrange timing

Avoid stacking Rhodiola Crenulata with Saffron Extract. If using both for different health goals, consult a healthcare provider about safe timing and dosing.

Reference

Reference noted for this combination: Gillman PK. Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. Br J Anaesth. 2005;95(4):434-441.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.