Can You Take Rhodiola Rosea and SAMe Together?

Use extra care with this pair

The short answer

SAMe increases serotonin availability, while Rhodiola Rosea has MAO-inhibiting properties. This combination may lead to excessive serotonin accumulation and increase the risk of serotonin syndrome.

How to arrange timing

Use caution when combining SAMe with Rhodiola Rosea. Consider using only one at a time, or consult a healthcare provider before combining.

Reference

Reference noted for this combination: Isbister GK, Buckley NA, Whyte IM. Serotonin toxicity: a practical approach to diagnosis and treatment. Med J Aust. 2007;187(6):361-365.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.