Can You Take Quercetin and Superoxide Dismutase Together?

Dose or timing may matter

The short answer

Quercetin can act as a pro-oxidant at certain concentrations, generating superoxide radicals as part of its hormetic signaling. Superoxide Dismutase directly neutralizes superoxide, potentially counteracting quercetin's beneficial stress-response activation.

How to arrange timing

If using quercetin for its hormetic pro-oxidant benefits, consider separating it from SOD supplementation.

Reference

Reference noted for this combination: Boots AW, et al. In vitro and ex vivo anti- and pro-oxidant activity of quercetin. Eur J Pharmacol. 2008;585(2-3):325-337.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.