Can You Take Progesterone Cream and Vitex / Chasteberry Together?

Dose or timing may matter

The short answer

Vitex increases endogenous progesterone by modulating pituitary LH output. Adding exogenous progesterone cream may produce excessive progesterone levels.

How to arrange timing

Consider using either Vitex or progesterone cream, not both, and monitoring progesterone levels.

Reference

Reference noted for this combination: Phytomedicine, 2003; 10(4): 348-357

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.