Can You Take Pregnenolone and Progesterone Cream Together?

Dose or timing may matter

The short answer

Pregnenolone converts to progesterone in the body. Adding exogenous progesterone cream may lead to excessive progesterone levels.

How to arrange timing

Consider using one progesterone source at a time and monitoring hormone levels.

Reference

Reference noted for this combination: Steroids, 2010; 75(10): 747-753

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.