Can You Take Phenibut and Skullcap Together?

Use extra care with this pair

The short answer

Phenibut's potent GABA-B agonism combined with skullcap's GABA-A effects may cause pronounced CNS depression.

How to arrange timing

Avoid combining without professional guidance.

Reference

Reference noted for this combination: Lapin, 2001, Eur Neuropsychopharmacol

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.