Can You Take Oxiracetam and Piracetam Together?

Dose or timing may matter

The short answer

Both Piracetam and Oxiracetam are racetams that increase acetylcholine utilization. Stacking two racetams may deplete choline reserves and cause headaches, fatigue, or reduced cognitive performance.

How to arrange timing

Supplement with Alpha-GPC or CDP-Choline when stacking racetams. Use lower doses of each to minimize choline depletion.

Reference

Reference noted for this combination: Malykh AG, Sadaie MR. Piracetam and piracetam-like drugs: from basic science to novel clinical applications. Drugs. 2010;70(3):287-312.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.