Can You Take Octopamine and Yohimbine Together?

Use extra care with this pair

The short answer

Octopamine increases norepinephrine release while yohimbine blocks its presynaptic negative feedback (alpha-2 receptors). Together, the unregulated norepinephrine surge may cause hypertensive crisis and cardiac arrhythmia.

How to arrange timing

Avoid this combination. The mechanism creates a positive feedback loop for sympathetic activation that is difficult to control.

Reference

Reference noted for this combination: Ostojic SM. Yohimbine: the effects on body composition and exercise performance in soccer players. Res Sports Med. 2006;14(4):289-299

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.