Can You Take Nattokinase and Trypsin Together?

Use extra care with this pair

The short answer

Both Trypsin and Nattokinase have fibrinolytic and proteolytic activity. Trypsin activates plasminogen and Nattokinase directly dissolves fibrin. Combining them produces a strong additive anticoagulant effect.

How to arrange timing

Use significant caution when combining Trypsin and Nattokinase. This combination substantially increases bleeding risk. Consult a healthcare provider before use.

Reference

Reference noted for this combination: Sumi H, et al. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto. Experientia. 1987;43(10):1110-1111.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.