Can You Take Nattokinase and Protease Together?

Use extra care with this pair

The short answer

Both Protease and Nattokinase have fibrinolytic activity. Combining them may produce an additive anticoagulant effect, significantly increasing the risk of bleeding.

How to arrange timing

Use caution when combining Protease and Nattokinase. Monitor for signs of excessive bleeding and consult a healthcare provider.

Reference

Reference noted for this combination: Sumi H, et al. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto. Experientia. 1987;43(10):1110-1111.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.