Can You Take Nattokinase and Neutral Protease Together?

Use extra care with this pair

The short answer

Both Neutral Protease and Nattokinase have proteolytic activity. Combining them may produce additive effects on protein degradation including fibrinolysis, potentially increasing bleeding risk.

How to arrange timing

Use caution when combining Neutral Protease with Nattokinase. Monitor for signs of excessive bleeding.

Reference

Reference noted for this combination: Sumi H, et al. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto. Experientia. 1987;43(10):1110-1111.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.