Can You Take NAC and Nitric Oxide Booster Together?

Dose or timing may matter

The short answer

NAC scavenges reactive nitrogen species and peroxynitrite, potentially reducing the bioavailability of supplemental nitric oxide and diminishing its vasodilatory and performance-enhancing effects.

How to arrange timing

If using nitric oxide boosters for exercise performance, avoid taking NAC close to workout time.

Reference

Reference noted for this combination: Aruoma OI et al. The antioxidant action of N-acetylcysteine. Free Radic Biol Med. 1989;6(6):593-597

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.