Can You Take Modafinil and Phenylpiracetam Together?

Use extra care with this pair

The short answer

Modafinil and Phenylpiracetam are both potent CNS stimulants. Modafinil affects dopamine, histamine, and orexin systems, while Phenylpiracetam modulates dopamine and acetylcholine. Combining them risks excessive CNS stimulation, cardiovascular stress, and insomnia.

How to arrange timing

Avoid combining two potent stimulant nootropics. If both are desired, use on alternate days rather than simultaneously.

Reference

Reference noted for this combination: Battleday RM, Brem AK. Modafinil for cognitive neuroenhancement in healthy non-sleep-deprived subjects: a systematic review. Eur Neuropsychopharmacol. 2015;25(11):1865-1881.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.