Can You Take Metformin (Off-label) and NAD+ Precursor Complex Together?

May affect absorption

The short answer

Both metformin and NAD+ precursors activate AMPK and affect cellular energy metabolism. Their combined effects on NAD+ metabolism may be unpredictable.

How to arrange timing

Consult a healthcare provider when combining metformin with NAD+ precursors. Monitor for hypoglycemia.

Reference

Reference noted for this combination: Examine.com

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.