Can You Take Ephedra and Yohimbine Together?

Dose or timing may matter

The short answer

Ephedra and yohimbine both raise blood pressure through sympathomimetic mechanisms. Ephedra stimulates alpha/beta receptors while yohimbine blocks alpha-2 autoreceptors. Combined use may produce dangerous BP elevation.

How to arrange timing

Research suggests avoiding this combination due to additive sympathomimetic cardiovascular effects.

Reference

Reference noted for this combination: Haller CA, Benowitz NL. Adverse cardiovascular events associated with ephedra alkaloids. N Engl J Med. 2000;343(25):1833-1838

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.