Can You Take Ephedra and Synephrine Together?

Dose or timing may matter

The short answer

Ephedra and synephrine (bitter orange) are both sympathomimetic agents that raise blood pressure. Combined use may produce additive or synergistic pressor effects, increasing cardiovascular risk.

How to arrange timing

Research suggests avoiding this combination. Both raise blood pressure and heart rate, and their combined effects may be unpredictable.

Reference

Reference noted for this combination: Haller CA, Benowitz NL. Adverse cardiovascular events associated with ephedra alkaloids. N Engl J Med. 2000;343(25):1833-1838

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.