Can You Take LL-37 and Zinc Together?

May affect absorption

The short answer

LL-37 antimicrobial peptide can be sequestered by divalent cations like zinc, which may alter its conformation and reduce its antimicrobial activity when taken simultaneously.

How to arrange timing

Separate LL-37 and zinc supplements by at least 1 hour to avoid interference with LL-37's antimicrobial function.

Reference

Reference noted for this combination: Vandamme D, et al. A comprehensive summary of LL-37, the factotum human cathelicidin peptide. Cell Immunol. 2012;280(1):22-35.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.