Can You Take Lithium Orotate and St. John's Wort Together?

Use extra care with this pair

The short answer

St. John's Wort increases serotonin availability, and Lithium Orotate enhances serotonergic neurotransmission. This stacking may contribute to excessive serotonergic stimulation.

How to arrange timing

Exercise caution when combining St. John's Wort and Lithium Orotate. Start with low doses and watch for signs of serotonin excess.

Reference

Reference noted for this combination: Dvir Y, Bhatt L, Bhatt DL. Serotonin syndrome with drug combinations. Pharmacotherapy. 2008;28(6):779-790.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.