Can You Take L-Tryptophan and Passionflower Together?

Use extra care with this pair

The short answer

L-Tryptophan increases serotonin availability, while Passionflower contains harmala alkaloids (harmine, harmaline) that inhibit MAO-A. This combination may lead to excessive serotonin accumulation and increase the risk of serotonin syndrome.

How to arrange timing

Use caution when combining L-Tryptophan with Passionflower. Consider using only one at a time, or consult a healthcare provider before combining.

Reference

Reference noted for this combination: Isbister GK, Buckley NA, Whyte IM. Serotonin toxicity: a practical approach to diagnosis and treatment. Med J Aust. 2007;187(6):361-365.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.