Can You Take L-Tryptophan and Melatonin Extended Release Together?

Use extra care with this pair

The short answer

Melatonin Extended Release provides sustained melatonin levels (a serotonin metabolite), and L-Tryptophan increases serotonin. The prolonged exposure may amplify serotonergic stacking effects.

How to arrange timing

Be cautious when combining Melatonin Extended Release with L-Tryptophan. The extended-release form prolongs the interaction window.

Reference

Reference noted for this combination: Foley HM, Steel AE. Adverse events associated with oral administration of melatonin. Complement Ther Med. 2019;42:65-81.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.