Can You Take L-Citrulline DL-Malate (2:1) and Nitric Oxide Booster Together?

Use extra care with this pair

The short answer

L-Citrulline DL-Malate is converted to L-Arginine, which produces nitric oxide. Taking additional NO boosters alongside provides redundant nitric oxide precursors, potentially causing excessive vasodilation and hypotension.

How to arrange timing

Research suggests choosing one NO precursor rather than stacking multiple. Monitor blood pressure if combining.

Reference

Reference noted for this combination: Schwedhelm E, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine. Br J Clin Pharmacol. 2008;65(1):51-59.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.