Can You Take L-Arginine and Yohimbine Together?

Dose or timing may matter

The short answer

L-Arginine lowers blood pressure via nitric oxide while yohimbine raises it as an alpha-2 adrenergic antagonist. The opposing effects may reduce the cardiovascular benefits of each.

How to arrange timing

These have opposing cardiovascular effects. Monitor blood pressure and heart rate when combining.

Reference

Reference noted for this combination: Galitzky J et al. Alpha 2-antagonist compounds and lipid mobilization. Int J Obes Relat Metab Disord. 1993;17(Suppl 3):S104-S109

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.