Can You Take L-Arginine and L-Norvaline Together?

Use extra care with this pair

The short answer

L-Norvaline inhibits arginase, the enzyme that breaks down L-Arginine. Combining L-Norvaline with L-Arginine may cause excessive accumulation of arginine and nitric oxide, potentially leading to hypotension.

How to arrange timing

Start with lower doses when combining L-Norvaline and L-Arginine. Monitor blood pressure, especially in those prone to hypotension.

Reference

Reference noted for this combination: Reczkowski RS, Bhatt D. Kinetic analysis of the role of arginase. Arch Biochem Biophys. 1994;312(1):31-37.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.