Can You Take Kratom and Vitamin B3 Together?

Use extra care with this pair

The short answer

Both Kratom and high-dose Niacin (B3) can cause liver injury. Kratom causes cholestatic damage via mitragynine, while sustained-release niacin is dose-dependently hepatotoxic.

How to arrange timing

Avoid combining Kratom with high-dose niacin. If niacin is needed, use immediate-release form and monitor liver function closely.

Reference

Reference noted for this combination: Kapp FG et al., Drug Alcohol Depend 2011; Guyton JR, Am J Cardiol 1998; LiverTox (NIH/NLM)

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.