Can You Take Kava and Vitamin B3 Together?

Use extra care with this pair

The short answer

Both Kava and high-dose Niacin (Vitamin B3) are hepatotoxic. Kavalactones cause hepatocellular damage, while sustained-release niacin causes dose-dependent hepatotoxicity through accumulation. Combined use may amplify liver stress.

How to arrange timing

Avoid combining Kava with high-dose niacin supplements. If taking niacin for cholesterol, use immediate-release forms at the lowest effective dose and monitor liver function.

Reference

Reference noted for this combination: Guyton JR, Am J Cardiol 1998; Teschke R., Ann Intern Med 2010; LiverTox (NIH/NLM)

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.