Can You Take Iron and Shiitake Extract Together?

May affect absorption

The short answer

Shiitake extract contains lentinan and other polysaccharides that may bind to minerals in the gastrointestinal tract, potentially reducing iron absorption.

How to arrange timing

Take iron supplements at least 2 hours apart from Shiitake extract to ensure adequate iron absorption.

Reference

Reference noted for this combination: Smiderle FR et al., Carbohydrate Polymers, 2008; Mushroom polysaccharides and mineral binding properties

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.