Can You Take Inositol and Lithium Orotate Together?

Dose or timing may matter

The short answer

Lithium depletes intracellular inositol by inhibiting inositol monophosphatase (IMPase), reducing the inositol phosphate signaling cascade. Supplemental inositol may counteract lithium's therapeutic mechanism.

How to arrange timing

If taking lithium orotate for mood support, consult a healthcare provider before adding high-dose inositol.

Reference

Reference noted for this combination: Berridge MJ et al. Neural and developmental actions of lithium: a unifying hypothesis. Cell. 1989;59(3):411-419

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.