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Can You Take Hydroxocobalamin and Vitamin C Together?
May affect absorption
The short answer
High-dose vitamin C (≥500 mg) may degrade hydroxocobalamin in the gastrointestinal tract by reducing the cobalt center, converting it to inactive cobalamin analogs.
How to arrange timing
Space hydroxocobalamin and high-dose vitamin C at least 2 hours apart.
Reference
Reference noted for this combination: Herbert V, Jacob E. Destruction of vitamin B12 by ascorbic acid. JAMA. 1974;230(2):241-242
Important context
Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.